M. Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements. Nucleic Acids Res. 38, 1841–1852 (2010). CAS PubMed Google Scholar Sfeir, A. & de Lange, T. Removal of shelterin reveals the telomere end-...
Adenosine triphosphate (ATP) is the energy currency within all living cells and is involved in many vital biochemical reactions, including cell viability, metabolic status, cell death, intracellular signaling, DNA and RNA synthesis, purinergic signaling, synaptic signaling, active transport, and muscle ...
Deletion of H2A.Z.2.1 in neural progenitor cells results in an abnormal increase in microglial numbers, likely due to the aberrant expression of C-X-C motif chemokine ligand 14 (Cxcl14). H2A.Z.2.1 recruits the H3K9 methyltransferase G9a to the promoter of the Cxcl14 gene, thereby ...
Abnormal tumor microenvironment and immune escape in multiple myeloma (MM) are associated with regulatory T cells (Tregs), which play an important role in maintaining self-tolerance and regulating the overall immune response to infection or tumor cells.
In acute ischemic heart injury, up-regulated Wnt is first expressed in the epicardium and subsequently in cardiac fibroblasts in the injured area. Wnt induces cardiac fibroblasts to proliferate and express pro-fibrotic genes. In addition to the role of Wnt, deletion of β-catenin in cardiac ...
Metabolic reprogramming is a pivotal biological process in which cellular metabolic patterns change to meet the energy demands of increased cell growth and proliferation. In this review, we explore metabolic reprogramming and its impact on fibrotic disea
Strong binding to self at the DP or SP stage in turn results in clonal deletion or diversion towards alternate T cell lineages through agonist selection [8], [95], [96]. There is a strict threshold between positive and negative selection in terms of self-reactivity, and only a small ...
Patrick is a 70-year-old diabetic man with a 2-year history of stable chest pain when he exerts himself. He is awoken from sleep with the acute onset of crushing central chest pain which radiates to his neck and left arm. His normal medications include normally aspirin, a diuretic, a ch...
Only HIF-1α and HIF-2α have a COOH-terminal transactivation domain (C-TAD)9. HIF-3α has been reported to exist as multiple variants, and some of the variants may lack one or more of the domains described above9. HIF-1α, HIF-2α, and HIF-3α protein stability is regulated by...
Neurotoxicity of lidocaine involves specific activation of the p38 mitogen-activated protein kinase, but not extracellular signal-regulated or c-jun N-terminal kinases, and is mediated by arachidonic acid metabolites Anesthesiology, 105 (2006), pp. 1024-1033 CrossrefView in ScopusGoogle Scholar 64. ...