Histone deacetylase (HDAC) inhibitors have been demonstrated to be beneficial in animal models of neurodegenerative diseases. Such results were mainly associated with the epigenetic modulation caused by HDACs, especially those from class I, via chromatin
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However, the question remained how this posterior tilt of cilia at the node is generated. Establishment of the three body axes, anterior–posterior (AP)-, dorso–ventral (DV)- and LR-axis, is central to the vertebrate body plan. Since the LR-axis is the last axis to be determined during...
However, the action of miRNAs on their mRNA targets is difficult to characterize, because each miRNA has multiple mRNA targets and vice versa; therefore, the correct identification of an interaction remains a challenge. The way to address this problem is usually through prediction and subsequent ...