The Sn2 rate is very sensitive to steric hindrance, while E2 is much less sensitive. So E2 is more likely to "win the race" in this situation. There is only one possible elimination product in the example you gave. So the product can't be described as either Zaitsev or Hoffman. But ...
The KIT receptor is normally in equilibrium between active and inactive conformations. The latter is favored by steric hindrance conferred by the juxtamembrane domain (exon 11), which prevents the activation loop from assuming the conformation required for kinase activation. With the knowledge that ...
What does steric effect actually mean? Reply James Ashenhurst September 5, 2019 at 12:54 pm “Steric effect” is the effect of the (non-bonding) electron clouds of atoms colliding with each other. It is a repulsive effect. In another post, I say “steric hindrance is like a fat goa...
Finally, domain D4 (residues 595–735) is a receptor-binding domain, which has little contact with the remaining domains. While the full-length PA83 binds to its cellular receptors, it cannot oligomerize forming a water-soluble channel because of steric hindrance between the D1a subdomains. ...
In the case of cerium dioxide nanoparticles, a decrease in the fertilizing capacity of the spermatozoa was observed which could either be secondary to this sperm DNA alteration or related to a steric hindrance on the surface of the sperm membrane, as described by Taylor et al. It should be ...
Stabilisation is ensured by electrostatic charge repulsion or by steric hindrance due to molecular structures projecting from the pigment surface in the binder [42]. These additives can prevent the flocculation problem when different pigments are mixed in the same paint. An example of a commercial ...
12. Kinetics and Mechanisms of Amyloid Formation Amyloids differ from amorphous protein deposits in the fact that they possess a highly ordered fibrillar morphology. It is worthwhile to discuss the kinetics alongside the various mechanisms that contribute to amyloid formation. For the purpose of enhance...