On the other hand, Toll-like receptor stimulation leads to B-cell activating factor promoting IgA class switching through a T-cell-independent pathway, ultimately stimulating IgA production. It is more probable that this antibody production is initiated by recruitment from other mucosal sites, such ...
Of central importance are pathogenic antiphospholipid antibodies (aPLs) which affect several cell types, including platelets, monocytes, trophoblastic, decidual, and endothelial cells as well as components of the coagulation and fibrinolytic systems. The result of these actions is an increased tendency ...
What is the impact of home-based HIV counseling and testing on the clinical status of newly enrolled adults in a large HIV care program in Western Kenya? This article describes the effect point of entry into the human immunodeficiency virus (HIV) care program had on the clinical status of ad...
Towards molecular farming in the future: Pichia pastoris-based production of single-chain antibody fragments This review article focuses on the use of the methylotrophic yeast Pichia pastoris as a recombinant protein-expression system. P. pastoris is a useful syst... R Fischer,J Drossard,N Ema...
aLebrikizumab (INN) is a humanized monoclonal antibody and an experimental immunosuppresive drug for the treatment of asthma that cannot be adequately controlled with inhalable glucocorticoids. The drug was created by Tanox under the name TNX-650, and a phase I clinical trial for refractory Hodgkin...
a substantial reduction in Treg frequency in high-risk MM patients [131]. The proportion of CD38+cells in Tregs was higher than that in effector T cells, and the level of CD38 was correlated with the expression level of Foxp3 [20]. Isatuximab, also a monoclonal antibody against CD38, ...
AMG133 (subcutaneous, every 4 weeks) is a monoclonal antibody that was designed to antagonise the GIP receptor and is also linked to two modified GLP-1 peptides that activate the GLP-1 receptor [58]. Results from a phase 1 trial have supported further clinical evaluation with a dose-depende...
In the infectious disease serology laboratory,or for serology testing within a core laboratory, some of thislogic is relevant, but it is not as simple as that [2]. Good QCpractices, including software, facilitates key decisionmaking around meaningful QC in infectious diseaseserology testing, as ...
G antigen of Rh blood group system is present either along with D and/or C positive red cells. Hence, [serologically anti-G presents with the similar pictu
In advanced non-small cell lung can- cer (NSCLC), FAP is related to a reduced density of CD8+ T cells and immunosuppressive TME status [18, 19]. In HER2+ and triple-negative breast cancer, the CAF subpopulation with high FAP expresses programmed death ligand-1/2 (PD-L1/2), ...