The slow release form, such as Glucophage XR, is available in 500 mg and 750 mg sizes and you can take it just once a day. The purpose of the slow release form is to reduce metformin's most notorious side effect, which is the disturbance of your GI tract. The usual dose is 850-1...
It may not sound as exciting as deer antler velvet but it is an “underdog” ingredient that is highly beneficial in enhancing HGH naturally by blocking “somatostatin” (the enzyme that limits HGH release) and facilitates better absorption of a variety of nutrients that could otherwise potentiall...
The conceptual leap that we make herein is that early type 2 diabetes is not a one-way proposition. This restyles the slope of the natural history of the disease to a far more favorable trajectory for our patients and with ample opportunities to slow or stall type 2 diabetes—from prediabe...
Which sometimes involves an emotional support human whose sole job is to remind me, from time to time, what it was that I am supposed to be doing when something shiny and interesting catches my attention, to bring me back on task, or to point to the small portion of the huge and overw...
These differences between the dissolution behaviour of formulations are likely to be most apparent when contractile activity is slow. Currently available in-vitro tools used to de-risk BE studies as recommended in BCS biowaiver guidance to date are limited to compendial paddle and basket set ups, ...
(metformin followed by add-on therapy with sulfonylurea and glargine insulin), while also achieving glycemic control in the EDICT study, did not simultaneously aid insulin sensitivity or substantially improve beta cell function. This finding supports the notion that intentional combination regimens reset ...
It is induced by short ubiquitin chains on the mitochondria [169]. Reviews on this process have been reported [168, 169] and discuss how metformin, an oral diabetes medication, both enhances and normalizes mitochondrial function that leads to alleviation of inflammation associated with aging [170...
It also is important that patients who are considering taking Fortamet® have healthy liver functions. When a patient who has irregular liver functions takes a drug containing metformins, lactic acidosis can occur. Lactic acidosis is a rare, but serious, condition that causes an accumulation of ...
Oral agents especially metformin and SGLT2 inhibitors should likely be stopped. Biguanides, of which metformin is the only one in use for patients with T2DM and pre-diabetes, are known to increase lactic acid production in the gut, which is then normally cleared in liver. However, as ...