Due to the complexity of NGS data and associated algorithms, NGS analysis is typically performed by bioinformatics specialists. To empower users who don’t have specialized bioinformatics training, platforms lik
Proteins Structure Function & BioinformaticsKarplus, K., R. Karchin, C. Barrett, S. Tu, M. Cline, M. Diekhans, L. Grate, J. Casper, and R. Hughey. 2001. What is the value added by human intervention in protein structure prediction? Proteins Struct. Funct. Genet. 45 : 86-91....
Learn about SAM & BAM files and how to read your raw alignment format in this blog, perfect for bioinformatics beginners.
In the second iteration of AlphaFold (AF2) the neural network model was entirely redesigned and the convolution approach was replaced by two novel transformer – based architecture modes [Citation27,Citation28]. The first mode, called Evoformer, utilizes multiple sequence alignment (MSA) ...
What is the difference between DNA, chromatin, and chromosomes and what is the significance of each form? How does bioinformatics help with finding mutations in DNA? Explain how the sequence of DNA impacts the function of the gene. Explain the reason why the cel...
The SI in Brassicaceae is sporophytic, meaning that expression of both male and female components can be affected by dominance interactions because the protein on the surface of the pollen is deposited by the diploid anther cells (Hatakeyama et al., 1998). The ancestral state of sporophytic SI...
Hamming Distance in Biology: In genetics and bioinformatics, Hamming distance aids in comparing DNA sequences. It measures the dissimilarity between genetic sequences, facilitating tasks such as sequence alignment, identifying mutations, and evolutionary analysis. It is also seen that Hamming distance ...
PICRUSt2 is carrying out several steps in order to get functional predictions for your data: 1. Finding the reference genomes that best match your sequences This is done by: Creating a multiple sequence alignment of your representative sequences against the PICRUSt2 database reference sequences. ...
Vector search is sometimes called “similarity search” or “nearest neighbor search” because of the way it facilitates grouping and matching of items to speed the search process. So, if someone asks for an image of a “happy dog in a park,” the vector search system will quickly and accu...
providing a biased view of the transcriptome. RNA-Seq is not limited to known sequences and produces a significantly larger data output. In addition to gene expression analysis, RNA-Seq can determine novel transcripts, alternative splice variants, single nucleotide polymorphisms (SNPs), insertions/del...