Sepsis is a perplexing infection-related syndrome documented for thousands of years. It remains a leading cause of mortality and morbidity worldwide. The concepts and understanding of sepsis have evolved in recent decades from a systemic inflammatory response syndrome to infection to, more recently, a...
CoV-2 Covid-19 Sepsis Acute pancreatitis Aging 1. Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a potentially life-threatening disease, defined as Coronavirus Disease 19 (COVID-19). This pathological condition is generally characterized by the presence of several ...
Flanders, MD JAMA JAMA Clinical Guidelines Synopsis Corticosteroids for Sepsis, ARDS, or Community-Acquired Pneumonia Peggy B. Leung, MD; Andrew M. Davis, MD, MPH; Joshua Davis, MD JAMA Community-acquired pneumonia (CAP) is a lung infection that is contracted outside of a hospital. In the ...
Low triiodothyronine syndrome is associated with hemorrhagic transformation in patients with acute ischaemic stroke. Aging. 2019;11(16):6385–97. Article CAS PubMed PubMed Central Google Scholar Ingels C, Gunst J, Van den Berghe G. Endocrine and metabolic alterations in Sepsis and implications ...
Fluid normally exchanges freely between the plasma and interstitial space and is returned primarily via the lymphatic system. This balance can be disturbed by diseases and medications. In inflammatory disease states, such as sepsis, the return flow of fl
Sepsis is defined as the systemic response to infection, manifested by some of the conditions for systemic inflammatory response syndrome. It remains the most common cause of death in medical and surgical intensive care units (ICU). Its incidence has grown...
This is a first hint of how targeting both the IL-6R forms with drugs like Tocilizumab might not be enough in a sepsis infectious model. Furthermore, it all points to the trans-signaling transduction being the harmful one (pro-inflammatory response), and the classic signaling transduction ...
Fluid normally exchanges freely between the plasma and interstitial space and is returned primarily via the lymphatic system. This balance can be disturbed by diseases and medications. In inflammatory disease states, such as sepsis, the return flow of fluid from the interstitial space to the plasma...
Article CAS PubMed PubMed Central Google Scholar Meisel C, Schefold JC, Pschowski R, Baumann T, Hetzger K, Gregor J, Weber-Carstens S, Hasper D, Keh D, Zuckermann H et al (2009) Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind...
Article PubMed Google Scholar Bakos O, Lawson C, Rouleau S, Tai LH. Combining surgery and immunotherapy: turning an immunosuppressive effect into a therapeutic opportunity. J Immunother Cancer. 2018;6(1):86. https://doi.org/10.1186/s40425-018-0398-7. Article PubMed PubMed Central Google ...