Cancer CellGoberdhan P.Dimri. (2005) What has senescence got to do with cancer?. Cancer Cell 7 , 505-512 /Dimri GP (2005) What has senescence got to do with cancer? Cancer Cell 7:505–512Dimri GP. What has senescence got to do with cancer? Cancer Cell. 2005; 7 :505–12. doi:...
Recently, it has become evident that anticancer treatment induces senescence in cancer cells. Moreover, certain hallmarks of senescence were detected in non-proliferating post-mitotic cells. There are many signalling pathways involved in cell senescence, but the most prevalent is the DNA damage ...
Identifying cellular senescence is of growing interest in cancer treatment, aging, developmental biology, and inflammatory disorders such as arthritis. Senescent cells have been implicated in contributing to age-related diseases such as Parkinson’s and diabetes, along with cancer resistance and metastasis...
Morphologically, cells that have undergone senescence have an enlarged and flattened shape and disrupted nuclear envelope integrity due to a decrease in the expression ofLamin B1. The formation of senescence-associated heterochromatin foci (SAHF) is a common form of chromatin reorganization observed in ...
Apart from a significant increase in our understanding of the mechanisms for uptake, cell clearance is a basic mechanism in tissue homeostasis, cancer, resolution of inflammation, induction of tolerance, and autoimmunity. Phagocytosis of dying cells is a complex process, involving many interacting ...
Cellularsenescenceis defined by permanent cell cycle arrest. Senescent cells accumulate with age and contribute to the normal aging process as well as age-related disorders. The link between senescence, aging, and age-related pathologies, including cancer, neurodegeneration, and metabolic and cardiovascul...
Senescence occurs with hTERT repression and limited telomere shortening in human oral keratinocytes cultured with feeder cells keratinocytes cultured with feeder cells - Kang - 2004 () Citation Context ...ation is frequently disrupted in cancer through the impairments of regulators... MK Kang,A Kamet...
As we grow older, aches and pains can become a chronic part of life. But experts say it doesn't have to—and solutions are on the way.
11细胞信号转导(CellSignaling)陈晔光清华大学生命科学学院ygchen@tsinghua.edu2ProliferationProliferationQuiescenceQuiescenceDifferentiationDifferentiationSenescenceSenescenceDeathDeathFatesofacellCancerCancerX3GeneralintroductionCommonfeaturesofsignaltransductionCellsurfacesignaltransducers,receptorsIonchannelsSecondarymessengerscAMPcGMPLi...
Cellular senescence is a process that results from a variety of stresses and leads to a state of irreversible growth arrest. Senescent cells accumulate during aging and have been implicated in promoting a variety of age-related diseases. Cellular senescence may play an important role in tumor suppr...