Design variation in studies investigating the effects of antibiotic use for chronic rhinosinusitis make drawing firm conclusions in systematic reviews difficult [32,33,34]. A Cochrane review concluded that there was little evidence that systemic antibiotics are effective in patients with chronic ...
Aside from physiological barriers, symptomatology such as a thick mucus layer in CF or rhinosinusitis in PCD complicate the process. In addition, to achieve the long-term expression needed in chronic conditions, repeated administrations are needed because of the constant cell renewal in the lung, ...