As is the case for depression-like behaviors, partial and bilateral dopaminergic denervation of the nigrostriatal pathway consistently induced anxiety-related behaviors (Table 1, but see ref.65). Anterograde and retrograde dopaminergic lesions of the dorsal striatum reduced the amount of time spent in ...
Neurotrophin 4 (NT-4) is also commoly known as Neu- rotrophin-5 (NT-5), or as NT-4/5[98, 139]. NT-4/5 forms part of the complex network of growth factors, along with BDNF, NGF, and NT-3, of retrogradely transported neurotrophins which orchestrate the generation and maintenance ...
The retrograde tracer is micro-infused into a specific projection target, is taken up by the axon terminals and is transported back to the cell body. It is possible to then to quantify the co-localization of the retrograde tracer signal (blue) and Fos expression (red) to analyze the ...
The hepatic expression of hAAT was achieved, but at lower levels than in mice, and AAT plasma presence could unfortunately not be detected, which is possibly due to a species-related issue (Figure 4) [131] Figure 4. Schema of hydrodynamic transfection within liver tissue in pigs. Retrograde ...