Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev. 15, 3237–3242 (2001). CAS PubMed PubMed Central Google Scholar Celli, G. B., Denchi, E. L. & de Lange, T. Ku70 stimulates fusion of dysfunctional telomeres yet protects ...
Neurodegenerative diseases typically involve deposits of inclusion bodies that contain abnormal aggregated proteins. Therefore, it has been suggested that protein aggregation is pathogenic. However, several lines of evidence indicate that inclusion bodie
Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy. Cancer Res 2005; 65: 8366–8371. CAS PubMed Google Scholar Wu-Zhang AX, Newton AC . Protein kinase C pharmacology: refining the toolbox. Biochem J ...
Streptococcus suis is one of the most important swine pathogens and can cause persistent infection in humans. Ding et al. showed that rhubarb can inhibit the formation of biofilms by downregulating transduction systems, influencing the levels of DNA binding protein and transcriptional regulation factors...
E, H2A.Z is implicated in DNA replication. H2A.Z licenses ORIs by recruitment of SUV4-20H1 and subsequent dimethylation of H4K20, leading to ORC1 binding. Red squares = methylation. CFDP1, craniofacial development protein 1; PRC1, polycomb repressive complex 1; UDG, uracil DNA glycosylase...
is also not clear. The identification of the central metabolic enzyme(s) thought to be involved would represent an important achievement, as knowledge of which spore protein is the weak link in spore core heat resistance might suggest strategies to improve the efficacy of spore wet heat killing....
Antrectomy (distal gastrectomy) is a procedure in which the distal third of the stomach (the gastric or pyloric antrum) is excised. Gastrectomies are further
A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response Cell, 167 (2016), pp. 1867-1882 e21 View in ScopusGoogle Scholar Agathocleous and Harris, 2009 M. Agathocleous, W.A. Harris From progenitors to differentiated cells in the vertebrate...
Polycomb group protein-associated chromatin is reproduced in post-mitotic G1 phase and is required for S phase progression. J. Biol. Chem. 283, 18905–18915 (2008). CAS PubMed Google Scholar Fanti, L. et al. The Trithorax group and Pc group proteins are differentially involved in ...
Bone morphogenetic protein ERK: Extracellular regulated protein kinase SSBE: Sedum Sarmentosum Bunge LDHA: Lactate dehydrogenase A TFE: Total flavonoids in Epimedium SPX: Ootheca Mantidis PTP: Peptidyl-tyrosine phosphorylation pathway DSS: Danggui Shaoyao San ...