PDGF-stimulated phosphorylation of S103/ S107 Hypoxia-mediated loss of PP1 activity Hypoxia-mediated ubiquitination PIAS1-induced modification with SUMO-1 Hypoxia mediated by SUMO-1 Hypoxia mediated by SUMO-1,2,3 Elevated CRTC/TORC interaction Nuclear import under high glucose...
the only human cathelicidin-family host defense peptide, alone or in combination with IL17A concomitantly induces expression ofHYAL1in human synovial sarcoma cell line SW982 (31). In fibroblasts, expression ofHYAL1was induced by platelet-derived growth factor (PDGF)-BB through activation of extracell...
PDGFRβ in CAFs can interact with PDGF-BB expressed by cervical cancer cells and promote can- cer cell growth by upregulating the expression of hep- arin-binding epidermal growth factor (HB-EGF) and activating the EGFR signaling pathway [81]. In CRC, PDGFRβ-labeled CAFs increase the ...
PDGF is a family of proteins comprising four different polypeptides (PDGF A–D) which can combine either as homodimers or heterodimers. The homodimer PDGF-BB has been involved in pericyte recruitment, maturation and survival through the binding on its specific receptor, namely the PDGFR-β, on ...
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Interestingly, the number of viable BCG bacilli in this study correlated with levels of GM-CSF, PDGF-AB/BB, IL-1β, TNFα and IFNγ, cytokines known to have roles in antimycobacterial and trained immunity [19], suggesting that the viability of BCG might affect the degree of innate ...
There are a number of potential factors that are not well understood in breast cancer, which are however better understood in prostate cancer, which is primarily osteoblastic [92]. At least one breast cancer-secreted factor, platelet-derived growth factor (PDGF)-β polypeptide B (BB), has ...
(PDGF) [57]; HER2, a membrane-bound protein belonging to the epidermal growth factor receptor family (EGFR) [58]; follistatin-like 1, a TGF-β inducible gene [59]; CCL24 [60]; CXCL6 [61]; CXCR4 [62]; OX40L, a T cell costimulatory signal molecule [63]; and CD25 (Treg cells)...
For 5 of the 12 TAPs assessed in this study (i.e., BTA, c-erbB-2, PDGF-BB, TPS, and hPLAP), we observed significant differences in serum levels between residents of the three municipalities. Differences in tumor-associated protein levels among middle-age Flemish women in association with...
PDGF-A PDGF-A PDGF-B PDGF-C PDGF-D PDGF-R PDGF-R-alpha PDGF-R-beta PDGF1 PDGF2 PDGFA PDGFA PDGFA-Associated Protein 1 PDGFB PDGFB PDGFB PDGFB PDGFC PDGFC PDGFD PDGFD PDGFR PDGFR PDGFR-1 PDGFR-2 PDGFR-alpha PDGFR-beta PDGFR1 PDGFR2 PDGFRA PDGFRA/BCR fusion PDGFRB PDGFRB PDGFRL...