Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type alleles in many inherited cancer syndromes. The wider involvement of LOH in cancer is assumed to relate to unmasking a somatically mutated tumour suppressor...
Rhubarb (also named Rhei or Dahuang), one of the most ancient and important herbs in traditional Chinese medicine (TCM), belongs to the Rheum L. genus from the Polygonaceae family, and its application can be traced back to 270 BC in “Shen Nong Ben Cao J
If the device is not supported, it is not a guarantee that ESXi will work properly with the device.If your device is not listed but is similar to a device that is listed, it may be possible to get ESXi to work with the device by creating a custom simple.map file. That process is ...
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med 2014;211(5):781–790. doi:10.1084/jem.20131916. (Open in a new window)PubMed (Open in a new window)Web of Science ®(Open in a new window)Google ...
Muscle glycogen supercompensation is enhanced by prior creatine supplementation. Med Sci Sports Exerc [Internet]. 2001 [cited 2024 Jun 13];33:1096–1100. Available from: https://pubmed.ncbi.nlm.nih.gov/11445755/(open in a new window) (Open in a new window)PubMed (Open in a new ...
in trends in mammalian evolution with a massive increase in the size of the cerebral cortex in primates. Here, we provide a timely overview of the current knowledge on the function of CDK5RAP2 and mechanisms that might lead to disease in humans when the function of this protein is disturbed...
It is apparent that MRAEs cause different levels of patient harm, with the most serious events resulting in an increase in morbidity and mortality worldwide [1,2,3]. The effects of the less serious cases are often poorly detected but are, however, known to decrease medication compliance and...
Genome expansion in three hybrid sunflower species is associated with retrotransposon proliferation. Curr Biol 16: R872–R873. Vagin VV, Sigova A, Li C, Seitz H, Gvozdev V, Zamore PD (2006). A distinct small RNA pathway silences selfish genetic elements in the germline. Science 313: 320...
perfusion of the left hemisphere with unilateral SACP; and with prolonged unilateral SACP, consider a second cannula for direct support of the contralateral side. Finally, the current warming trend in aortic arch surgery places the spinal cord at risk during SACP. This is probably not an all-or...
Background and Objectives: The K- ras gene is one of the most extensively investigated oncogenes in a wide variety of human tumors, but has rarely been studied in distal bile duct carcinoma (DBDC). We sought to investigate the diagnostic and prognostic value of K- ras codon 12 mutations ...