Paclitaxel is a widely used drug developed since the mid-1980s, with significant antitumor activity against ovarian, head and neck, bladder, breast and lung cancers. Paclitaxel promotes microtubule assembly and stabilizes microtubule dynamics, inhibiting cell proliferation and induction of apoptosis. Pacli...
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Patient-reported peripheral neuropathy of doxorubicin and cisplatin with and without paclitaxel in the treatment of advanced endometrial cancer: Results fr... In GOG 184, the addition of paclitaxel to cisplatin and doxorubicin offered no additional clinical benefit, yet was associated with increased prov...
Carboplatin is a second-generation platinum compound analog with established activity against a broad spectrum of solid tumors including brain tumors, neuroblastoma, rhabdomyosarcoma, and germ cell tumors. It is commonly used for pediatric cancer and approximately one-third of children with solid tumor ...
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The Preferred National Comprehensive Cancer Network (NCCN) guidelines for adjuvant chemotherapy for high-risk HR- breast cancer patients recommend regimens with doxorubicin plus cyclophosphamide followed by paclitaxel or docetaxel plus cyclophosphamide [329]. The EBCTCG meta-analysis evaluated the benefits of...
Today, first-line standard therapy includes tumor debulking surgery (removal of all visible tumors), followed by six cycles of combination Paclitaxel/carboplatin administered intravenously every three weeks. Ovarian Cancer; Treatment More results ► Acronyms browser ? ▲ PACIDN PACIF PACIFIC PACIFICS ...
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We conducted an ancillary analysis to determine an appropriate second-line regimen for patients who received a platinum agent as first-line chemotherapy. Methods We extracted and reanalyzed data of patients treated with doxorubicin and cisplatin (AP), paclitaxel and carboplatin (TC), or docetaxel ...