Similarly, AA metabolism is essential in renal fibrosis. As the most abundant AA in the body and a substrate for protein synthesis, glutamine is involved in several metabolic pathways and plays a particularly crucial role in renal fibrosis. For example, glutamine can prevent apoptosis in human pro...
Sarcopenia is characterized by a chronic deficit in muscle protein storage, which re- sults in the progressive loss of muscle mass quality and strength and/or physical perfor- mance [1,26–28]. So far, two distinct forms of sarcopenia have been described: age-medi- ated...
The liver is essential for processes such as metabolism, drug detoxification and plasma protein production. The two major parenchymal cell types in the liver are hepatocytes and biliary epithelial cells (BECs; cholangiocytes). Hepatocytes perform most of the liver functions, while bile ducts formed ...
p53 is phosphorylated and activated by ATM and ATR protein kinases. Activated p53 increases the P21 production in the cell, and by preventing phosphorylation of retinoblastoma protein activates P21, subsequently, stops the cell cycle in G1 phase so that repairing...
Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy. Cancer Res 2005; 65: 8366–8371. CAS PubMed Google Scholar Wu-Zhang AX, Newton AC . Protein kinase C pharmacology: refining the toolbox. Biochem J ...
These findings were associated with decreased protein expression of p65 NF-kappa B. Conclusions: Although short-term pressure-overload results in compensatory LVH with normal cardiac function, NF-kappa B inhibition resulted in increased LVH that was associated with functional deterioration. These ...
Markers of CAFs derived from MSCs Vimentin Vimentin is a type III intermediate filament protein that acts as a cytoskeletal protein and is localized to the cyto- plasm. It is an EMT biomarker that maintains cell struc- ture and motility during cell migration. In the TME, it is expressed...
is treated with TOLL body 4 (TLR4), NF-κB, epoxy enzyme-2 (COX-2), induced nitrogen dioxide The expression of synthase, nitric oxide (NO), and ICAM-1 [. Consistent,Polydatinmay play an important role in preventing inflammation by reducing the fibrobine activated protein kinase(mapks). ...
It has been indicated that NF-κB p65 which is upregulated in human bladder cancer cells significantly enhanced the cancer cell migration by stabilizing the activity of FBXW7 which in turn ubiquitylated and induced degradation of RHO guanosine diphosphate dissociation inhibitor (RhoGDI)-α protein. ...
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