He had a history of depression and substance abuse (cocaine). His physical examination was unremarkable, except for agitation. His baseline electrocardiogram (ECG) demonstrated a normal sinus rhythm and a QT/QTc of 484/475 milliseconds at a pulse of 58 beats per minute. The patient was given ...
For oral treatment of moderate to severe tremor resistant to usual PD medication, suvecaltamide, a T-type calcium-channel modulator, is currently evaluated in a recently initiated phase 2 study (NCT05642442). Three well-established device-aided therapies have been used in advanced PD since the ...
Douglas Thomson, trademark attorney at Marks & Clerk, added: “Cybersquatting – whereby opportunists buy up branded domain names in the hope of re-selling them – is a problem across the net, but has the potential for uniquely embarrassing and damaging consequences in this case. “The only ...
What is the likely underlying channelopathy in this patient? Figure 1A reveals sinus rhythm at 60 bpm with a prolonged QTc interval (~520 ms) showing the classical morphology of type 3 long QT syndrome (LQTS3) with a prolonged isoelectric ST segment, followed by a delayed normal T wave. ...
While the blood–brain barrier (BBB) limits the penetration of some systemic agents into the normal central nervous system, it is largely disrupted by brain metastases. Many systemic agents can achieve high drug concentrations in brain tumors, leading to similar response rates for treatment-naïve...