Cutaneous T cell lymphomaCutaneous lymphomaNon-melanoma skin cancerReview CTCLThis review focuses on updates in prognosis, pathogenesis, and treatment of cutaneous T cell lymphoma (CTCL).#Cohort studies indicate
High-grade B-cell lymphoma Cutaneous B-cell lymphoma Hairy cell leukemia Causes of B-Cell Lymphoma These cancers begin when lymphocytes grow out of control. Doctors don't know what makes that happen. The role of lymphocytes There are two main types of lymphocytes, called B cells and T cells...
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat. Cell Biol. 7, 712–718 (2005). CAS PubMed Google Scholar Sfeir, A., Kabir, S., van Overbeek, M., Celli, G. B. & de Lange, T. Loss of Rap1 induces telomere recombination in the...
targeting CCR4, indicated for cutaneous T-cell lymphoma (Ishii et al., 2010). As mentioned, structural knowledge on the family of GPCRs has substantially increased over the past years, and both NMR and X-ray crystallography approaches have been successfully applied for solving chemokine receptor ...
Sézary syndrome is quite rare. Each year in the U.S., there are about 3,000 new cases of cutaneous T-cell lymphoma, about 15% of which are Sézary syndrome. The disease can affect anyone, but it is more common in people ages 50 and older. It’s slightly more common in men than ...
Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumor
Wondering what the difference is between STIs (sexually transmitted infections) and STDs (sexually transmitted diseases)? The STI Project is here to give you the low-down! STI and STD are often used interchangeably. More recently, the term STI has risen in popularity over STD in public health...
Figure 1. Immune checkpoints and the effect of monoclonal immune checkpoint inhibitor antibodies on T-cell function. In the lymph tissue, T cells are quiescent but can be activated by antigen presentation by an antigen-presenting cell. Antigen binding to the T-cell receptor (TCR) is modulated ...
Bouras, T. et al. Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell 3, 429–441 (2008). Article CAS PubMed Google Scholar Tam, W. L. et al. Protein kinase Cα is a central signaling node and therapeutic target for breast cancer stem...
Second, how many of these peptides stimulate T-cells?; third, what are the critical protein modifications involved in T-cell activation; and finally, what is the role of hapten-specific T-cells in the iatrogenic disease? These questions will become increasingly important as more and more target...