Multiorgan dysfunction syndrome (MODS) was defined by the ACCP/SCCM conference almost 20 years ago as the situation in an acutely ill patient whereby organ function is disrupted such that it is unable to maintain homeostasis. Importantly, MODS is a dynamic process, changing over time according ...
Abnormal tumor microenvironment and immune escape in multiple myeloma (MM) are associated with regulatory T cells (Tregs), which play an important role in maintaining self-tolerance and regulating the overall immune response to infection or tumor cells.
Which of the following is not an autoimmune disease? (a) Multiple sclerosis (b) Myasthenia gravis (c) Type I (insulin-dependent) diabetes (d) Rheumatoid arthritis (e) Botulism. What are SIRS and ARDS? What causes these conditions when a patient has multipl...
Baue AE. The role of the gut in the development of multiple organ dysfunction in cardiothoracic patients. Ann Thorac Surg. 1993;55(4):822-829. doi:10.1016/0003-4975(93)90098-3. Leprat R, Michel-Briand Y, Thouverez M, Rozenbaum A, Arlet G, et al. Septicémies à Pseudomonas aeruginosa...
H. Pharmacokinetic assessment of multiple ATP-binding cassette transporters: the power of combination knockout mice. Mol. Interv. 9, 136–145 (2009). CAS PubMed Google Scholar Kruh, G. D., Belinsky, M. G., Gallo, J. M. & Lee, K. Physiological and pharmacological functions of Mrp2, ...
There are evidences that psychological factors, in which IBS patients differ from the normal individuals, have a role in the severity and duration of IBS, but it is not clear which of them are important and how they interact. To find it out, a multiple test battery was applied in a model...
Intensive care, also known ascritical care, is a multidisciplinary and interprofessional specialty dedicated to the comprehensive management of patients having, or at risk of developing, acute, life-threatening organ dysfunction. Intensive care uses an array of technologies that provide support of failing...
Mitochondrial dysfunction contributes to metabolic issues likeobesity, insulin resistance, and type II diabetes, as well as cardiovascular disease.24,38,39 PQQhelps improve many factors that contribute to metabolic syndrome. PQQ affects insulin signaling via multiple pathways. That is why studies suggest...
Since the renaissance of microbiome research in the past decade, much insight has accumulated in comprehending forces shaping the architecture and functionality of resident microorganisms in the human gut. Of the multiple host-endogenous and host-exogeno
In interconnected systems, a malfunction in one part can lead to dysfunction in another, especially if the initial problem is not promptly addressed. 8 Is dysfunction more complex to resolve than malfunction? Often, yes, because dysfunction may involve multiple factors and systems, requiring a more...