Abnormal tumor microenvironment and immune escape in multiple myeloma (MM) are associated with regulatory T cells (Tregs), which play an important role in maintaining self-tolerance and regulating the overall i
In addition to the above markers of Treg cells, there are many other molecules involved in their immunosuppressive function. CTLA-4 is a negative regulator of T cell activation that shares the molecular ligand CD80/CD86 with CD28 and has a higher affinity [42]. CD80/CD86 is expressed on matu...
She expresses concern over the Inflation Reduction Act (IRA), noting both positive aspects, such as the $2000 cap on patient out-of-pocket expenses, and negative impacts, such as inequitable reimbursement structures that could financially strain community phar...
Patient 1: Patient is a 58 year old man with Philadelphia chromosome negative B cell ALL who undergoes treatment with HyperCVAD (alternating cycles of daunorubicin, prednisone and vincristine with high dose methotrexate and cytarabine and intrathecal prophylaxis and achieves CR1. He undergoes a non-...
smoldering multiple myeloma; immunotherapy; clinical trials; progressive disease; prognostic factors; quality of life; overall survival1. Introduction In the continuous spectrum of monoclonal gammopathies, smoldering multiple myeloma (SMM) occupies an intermediate position between what is usually referred to...
Newer Trials Explore High-Risk Treatment and MRD in Multiple Myeloma Targeted Oncology Staff May 9th 2025 Article During a live event, Kathleen A. Dorritie, MD, discussed updated outcomes from the IsKia, MASTER, and CONCEPT clinical trials of frontline therapy in multiple myeloma. ...