Multiple myeloma typically begins as monoclonal gammopathy of undetermined significance (MGUS), which is a precancerous condition in which asymptomatic people have an antibody or pieces of antibody called monoclonal protein (M protein) in their blood. MGUS affects an estimated 3% to 5% of people ag...
Nephrotic syndrome: This is a group of symptoms that occur when the kidneys are not able to filter waste products from the blood properly. Symptoms may include swelling in the face, feet, and hands, as well as foamy urine. Toddler may seem uncomfortable but they can not tell symptoms. Neph...
Your results will also show the range of your protein levels. Ideally, it should be normal and not too high or low. If your doctor diagnosesmonoclonal proteinsor M-proteins, that will indicate that you have multiple myeloma. The doctor will then conduct some more tests to confirm these resul...
The importance of using the serum protein electrophoretic pattern in determining the magnitude of the monoclonal immunoglobulin component and the need for accurate quantification and characterization of urine protein are emphasized. Uniform definitions and consensus on diagnostic standards are becoming ...
Louis encephalitis virus, West Nile virus, tick-borne encephalitis virus, Langat virus, Powassan virus, Modoc virus, Rio Bravo virus) in terms of genome size and genome organization [1, 2] (Fig. 1). The genome is ~10.7 kb in length and codes for a single polyprotein (~10.2 kb), ...
Bacteria can be detected as particles in liquid samples in the case of bacter- aemia and bacteriuria, and can also be identified using polyclonal or monoclonal antibodies that are coated with fluorescent molecules. FCM has been applied successfully to the detection of a wide range of bacte- ria...
aDD23 monoclonal antibody recognizes a 185-kDa antigen expressed by bladder cancer cells and has been proposed as an adjunct to cytology for the detection of bladder cancer (319,320). Urine fibronectin (321,322) and human chorionic gonadotropin (HCG) β subunit and β core fragment (protein ...
Hand Schuller Christian Syndrome:Also known as Langerhan's cell histiocytosis, it is associated with a lethal form of blood cancer in children POEMS Syndrome:Peripheral neuropathy, organomegally, endocrinopathy, monoclonal paraproteinaemia, and skin lesions. This is associated with vascular tumours ...
In patients with type 2 diabetic nephropathy, bremelanotide demonstrated efficacy in reducing urine protein to creatinine ratio and improving or stabilizing estimated glomerular filtration rate. Driving Diversity with the Integrated Research Model Andy Studna, Editor ...
The limit of 240 mOsm/kg given in the European Pharmacopoeia for monoclonal antibodies14 has already a considerable safety margin and seems a bit arbitrary acceptance criterion but is not the physiologically lowest limit conceivable for these products. Indeed, a hypotonic sodium chloride 0.45% in...