Detection of methylation is challenging from both technical and biological perspectives. Tumour and cell type heterogeneity may influence the degree of methylation detected, so we also took an alternative approach where we used the methylation array data to test whether there were genes that were more...
Nucleotide sequence of the locus, microheterogeneity at the 5'-end of beta-globin mRNA, and aberrant nuclea... We have determined the nucleotide sequence of the adult chicken beta-globin gene locus. The structure of the adult chicken beta-globin gene is, for the mos... D Maclagan - 《...
Secondly, several studies have suggested that other HLA loci, such as HLA-C and -DQ locus, may contribute to poorer graft outcomes [48,49,50], but this meta-analysis only included the HLA-A, -B and -DR loci. Thirdly, heterogeneity is inevitable in some outcomes. We conducted several ...
was 0.09 for performance-based self-esteem, 0.12 for job engagement, and 0.53 for leader-member-exchange. However, according to Kahn (2011), using multilevel modeling even with low ICCs is sensible, as ICCs as low as 0.10 can imply meaningful heterogeneity between...
NESTED HETEROGENEITY, AND NEW VALUE CREATION: PHILOSOPHICAL CONSIDERATIONS ON THE LOCUS OF KNOWLEDGE At what level is new value created, or, put differently, what is the locus of knowledge? While knowledge and capabilities-based researchers argue that the locus of new value and knowledge lies at ...
We observed no significant association between HLA-B locus and overall graft failure (HR: 1.01; 95% CI: 0.90–1.15). In subgroup analyses, we found recipient sample size and ethnicity maybe the potential sources of heterogeneity. HLA mismatching was still a critical prognostic factor that affects...
between different research groups can provide a sizeable study, but both approaches require a high level of vigilance about locus and disease heterogeneity when data come from different populations. Spurious associations are often due to population stratification, cryptic relatedness and differential bias ...
Opitz syndrome is genetically heterogeneous, with one locus on Xp22, and a second on 22q11.2. Nature Genet. 11, 459–461 (1995). Article CAS Google Scholar Vortkamp, A., Gessler, M. & Grzeschik, K.-.H. GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families....
individual studies are very heterogeneous in their structure and design. Heterogeneity was identified regarding the plant species, the CRISPR-variant, the prediction tools and detection methods used, the amount of tolerated mismatches and the chosen sgRNA. In order to allow any conclusions to be drawn...
This locus, named flamenco in the case of gypsy, is responsible for the formation of TE-derived piRNAs that regulate transposon activity through the Piwi pathway (Brennecke et al., 2007). The subtelomeric site 1A, located in the X chromosome (X-TAS locus), contains several P element ...