This led them to conclude that the protein might function as part of a signalling pathway involved in the regulation of ageing and related diseases. One year later, the same group isolated the human homologue of the Klotho gene and determined its structure .Drueke TBPrie D...
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aThe secreted Klotho protein controls multiple ion channels and growth 被藏匿的Klotho蛋白质控制多种离子渠道和成长[translate] asend of assalso 送 assalso[translate] aIl sort de la piece avec la carte a la main. 它离开与部分与图对手。[translate] ...
aThe secreted Klotho protein has a putative sialidase activity that modifies glycans of calcium channel TRPV5 on the cell surface. 被藏匿的Klotho蛋白质有在细胞表面修改钙渠道TRPV5 glycans的想像sialidase活动。[translate] ai dot't like your imagination of so great i dot't喜欢您的想像力很伟大[transl...
a以肾脾阳虚对Klotho蛋白表达的影响为切入点 Take the kidney spleen deficiency of yang to the Klotho protein expression influence as the breakthrough point[translate] a顺便说一下,我们军训的时候天气总是很凉 While convenient said, our military training time weather very is always cool[translate] ...
Cutaneously synthesised or ingested vitamin D is subsequently transported to the liver, usually bound to a vitamin D binding protein (DBP), where hydroxylation on the 25-position by hepatic CYP2R1 (25-hydroxylase) yields 25-hydroxyvitamin D (25(OH)D). The hormonally active 1,25-...
The researchers have found that reducing the function of a transmembrane protein, called Klotho, in obese mice with high blood sugar levels produced lean mice with reduced blood sugar levels. New discovery paves way for anti-obesity pill The lack of characterized transmembrane signaling proteins in...
Homozygous mutant klotho (KL(-/-)) mice exhibit multiple phenotypes resembling human aging. In the present study, we focused on examining the pathology of the lungs of klotho mice and found that it closely resembled pulmonary emphysema i... T Suga,M Kurabayashi,Y Sando,... - 《American Jo...
is eating, say, 2500 calories per day. However, given my caloric demands – and the requirement that I keep protein intake limited – I really need to go out of my way to ensure I’m not eating too much protein. I will be writing about this in much greater detail in a future post...
more work is needed. Some data connecting elevated Piintake to accelerated aging have recently appeared, in the form of studies of mice-bearing mutations in the gene Klotho (John et al. 2011), which acts with FGF23 to regulate kidney Pitransport. Mice lacking either FGF23 or Klotho show ...