The Biological Impact of Oxidative Metabolism in Trypanosomatid Parasites: What Is the Perfect Balance Between Reactive Species Production and Antioxidant Defenses?Chapter First Online: 27 October 2019 pp 127–173 Cite this chapter Oxidative Stress in Microbial Diseases ...
A good meal cannot be defined in an absolute manner since it depends strongly on where and how it is eaten and how many people participate. A picnic shared by hikers after a challenging climbing is very different from a birthday party among a family or a banquet for a large convention. Al...
This review provides updated information of the expression, function, and transport kinetics in the intestine of known Met-linked transporters along with putative MHA-linked transporters. As a neutral amino acid (AA), the transport of DL-Met is facilitated by multiple apical sodium-dependent/−...
In addition, COVID-19 pointed on the possible solutions for the environmental pollution globe problem. Therefore, this review aims to address SARS-CoV-2, its transmission, where it can be found, why it is severe in some people, how it can be stopped, its diagnosis and detection techniques,...
The potential impact of resistance mechanisms on the new agents is assessed and the ways in which PK/PD studies are used to design dosing regimens for the new agents, especially combinations, as well as to improve dosing of existing antibiotics are discussed....
is also possible. This form of cell death is similar to apoptosis, but the degradation of the cellular machinery, especially the DNA, is not initiated by caspases, but rather by alternate enzymes. Third, regulated cell death may occur via differential regulation of the autophagy pathway in some...
Although the rats used in the present experiment are genetically identical siblings, there is a natural variability in their baseline levels of anxiety-like behaviour, which can be further influenced by environmental stressors. To determine how important optimal donor selection is, the two cages of ...
Non-alcoholic fatty liver disease (NAFLD) is a serious health problem due to its high incidence and consequences. In view of the existing controversies, new therapeutic options for NAFLD are still being sought. Therefore, the aim of our review was to eva
Figure 1 illustrates such CPP-assisted strategies in achieving intracellular delivery of the drug payloads. 2.1. Covalent Conjugation of Therapeutic Agents with CPP The commonly used strategy for CPP-assisted drug delivery is by covalent conjugation, either chemically or biologically, of CPPs with the...
A second enzyme, glutamic acid decarboxylase (GAD), cat- alyzes the decarboxylation of glutamic acid into GABA. Conversely, in the presence of α-ketoglutarate, GABA is degraded by GABA-T into succinic semialdehyde and glutamic acid; succinic semialdehyde can be oxidized into succinic acid, which...