Point Mutation CDR3 for TCR Viral + COVID-19 Coronavirus HIV & SIV Infectious Disease Zika Virus Pathways + AKT JAK STAT WNT B-Catenin Neuroscience + Neuroscience Neural Development Neuronal Cell Types Learning and Memory G-protein-coupled Receptors & Ion Channels ...
In ENKTL, PD-L1 overexpression is possibly related to different factors. The EBV-related oncoprotein LMP1 is one of the mechanisms driving PD-L1 overexpression through the NF-kB pathway [72]. In ENKTL, both JAK/STAT and NF-kB are usually activated, and multiple recurrent genetic and epigenetic...
found that the male-specific genes FBXL7, ITPR3, and ALOX15 are increased and RAD51B decreased in asthma, while a female-specific gene HLA_DQA1 is decreased. Additional differences were observed for more male-specific hypoxia-inducible factor 1 signaling pathways and for more female-specific IL...
JAJA JAJC JAJHS JAJO JAJP JAJRN JAJYC JAK JAK-STAT JAK/STAT JAK1 JAK2 JAKA JAKE JAKER JAKES JAKF JAKIM JAKIP JAKLI JAL JALA JALAM JALANA JALAS JALAS&L JALAWT JALB JALBCA JALBTCX JALC JALCA JALD JALDA JALE JALECO JALEPV ▼...
3). Constitutive activation of JAK1 in a mouse model leads indeed to the development of a SLE-like clinical picture, simultaneously characterized by the constant presence of PSVD/NRH lesions [135]. When to suspect PSVD: tips for the rheumatologist The diagnostic algorithm of PSVD is ...
Restricted to primates, alternative splicing of the H2AFV gene produces an isoform called H2A.Z.2.2, which has a shortened and unique C-terminus. This alteration leads to destabilization of the nucleosome structure when H2A.Z.2.2 is incorporated into chromatin (15,16). Download: Download high-...
Liver fat storage, also called hepatic steatosis, is increasingly common and represents a very frequent diagnosis in the medical field. Excess fat is not without consequences. In fact, hepatic steatosis contributes to the progression toward liver fibrosi
IFN-γ is considered a master regulator of the immunopathology in CD. Functional variants of IFN-γ gene have been associated with CD susceptibility. It has been demonstrated that the Janus kinase-signal transducer and activator of transcription (JAK-Stat) pathway is implicated in the pathogenesis ...
Neuro-inflammation is one of the major hallmarks associated with a wide range of CNS disorders [20]. During infection,IFNsandtumor necrosis factor-α (TNF-α)genes trigger initial responses of the innate immune system. Upon activation, IFNs induce the expression of IFN-stimulated gene (ISG) ...
SCID is a primary immune deficiency disease caused by genetic defects that affect the function of T cells and B cells. Cause CVID is caused by TACIgene mutation. SCID is caused by mutations in IL2RG gene, ADA gene, PNG gene, AK2 gene, RAG-1 and RAG-2genes, JAK3 gene, Artemis gene...