The short-term reduction of Tregs was enough to achieve long-term and stable remission of MM [81]. Effector Tregs are the most abundant cell type among Foxp3+ T cells in tumor tissues [149], and the selection of their surface specific targets is expected to activate antitumor immunity ...
The immunosuppressive function of Tregs depends on continuous expression of the transcription factor Foxp3, which is also a hallmark of the completion of Tregs differentiation [25]. Foxp3 controls the proliferation, inhibitory function and homeostasis of Treg cells by regulating oxidative phosphorylation ...