36 This is not so much an issue considering human T2DM patients also display a wide range of glucose intolerance and insulin resistance; however, the major limitation is that these data are not reproducible among research groups and therefore cannot be reliably extrapolated across species. Levin et...
The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pan... The incretin effect is reduced and the insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) is abolishe...
Bacha F, Gungor N, Lee S, Arslanian SA 2009 In vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes. Diabetes Care 32: 100 -105...
From the obesity perspective, He and colleagues53have demonstrated that insulin treatment alone is sufficient to increase HIF-1α mRNA and protein levels in differentiated 3T3-L1 adipocytes53. Interestingly, high glucose levels in normal cultured cells have been reported to reduce HIF-1α protein lev...
Importantly, WD withdrawal normalized impaired glucose intolerance in mice fed with HP-Trans-WD (Figure 6E,F). Figure 6. Effects of WD withdrawal on MS. (A) Mice were fed for 14 weeks with WD followed by 3 weeks of withdrawing. Effects of WD withdrawal: (B) Body and (C) Liver ...
An alteration in sensory processing, which happens when the capacity to behave in response to sensory information such as sound, touch, body movement, sight, taste, and smell is impaired, is a key component of ASD that has recently attracted increasing attention. This change may eventually ...
suggested that increased insulin resistance combined with beta cell dysfunction is associated with the severity of glucose intolerance and total insulin dosage required for GDM patients.2425 The deficiencies might become manifest due to the women's' hormonal changes during pregnancy such as corticosteroids...
60 % of the 29 patients with glucose intolerance or diabetes (p< 0.0001) were defined as responders (a ≥ 25 % reduction in glucose on a standard oral glucose tolerance test as measured from baseline to 24 weeks). There was a continued improvement in glucose tolerance measured at each of ...
The impact of probiotic strains on host health is widely known. The available studies on the interaction between bacteria and the host are focused on the changes induced by bacteria in the host mainly. The studies determining the changes that occurred in the bacteria cells are in the minority....
Many studies propose bile acids as promising candidates for treating chronic metabolic diseases because they are most frequently associated with impaired lipid metabolism and impaired glucose metabolism [5]. Our comprehension of the mechanism between BA and chronic metabolic diseases is expanding, and ...