We need to understand the interplay between neonatal gut microbiome assembly and breastmilk and will likely find bioactives derived from bacteria, potentially induced by breastmilk, with activities that act directly on human cells within the gut but also at systemic sites impacting immunological, ...
Sex differences in psychiatric disorders are the result of a complex interplay between genetic, hormonal, immunological, and psychosocial factors [2,3,16,17,18,19,20,21,22,23]. Adding to this complexity, the diagnosis of psychiatric disorders is currently based on behaviorally defined DSM criteria...
As such, the relationship between the T cell and self is dynamic and evolves over time. Here we discuss the role of the self-immunopeptidome in establishing naive T cell heterogeneity throughout a T cell’s life and ask what the distinct roles of self-mediated thymic imprinting versus ...
Dobosz P, Stempor PA, Ramírez Moreno M, Bulgakova NA (2022) Transcriptional and post-transcriptional regulation of checkpoint genes on the tumour side of the immunological synapse. Heredity https://doi.org/10.1038/s41437-022-00533-1 Dong C, Yoon W, Goldschmidt-Clermont PJ (2002) DNA methylat...
On the other hand, the adaptive immune system takes longer to develop, is antigen-specific, and capable of immunological memory. Infection and septicaemia Traditional Chinese medicine has for centuries used fungi for healing and recent interests have focused on polysaccharides, that are a crucial ...
this is the absence of Operation Warp Speed-like funding and lack of a pandemic situation, which required prioritization of vaccine development on all levels. Second, the immunological problems that need to be solved with universal vaccines are very different in nature from the simple induction of...
An efficient antitumor response requires high energy usage, particularly in producing and trafficking cytokines and cytolytic molecules into the immunological synapse via the action of cytoskeletal activities.117,118 It is therefore not surprising that our group found that the CD103+ CTA-specific CTLs ...
Another comment often made about the BCG vaccine is that it fails to induce long-lasting immunity, generally assumed to be mediated by classical T-cell memory. Again, this is not correct, as despite concerns about the induction of long-term immunological memory by BCG in mice, in certain set...
(iii) INDOLE 3-BUTYRIC ACID RESPONSE 5 (IBR5); and, (iv) AUXIN BINDING PROTEIN 1 (ABP1), which is the oldest known putative auxin receptor [5,6]; however, these latest findings were put into question when ABP1 was found to have little, if none, prominent role in Arabidopsis ...
Down syndrome is a well-studied aneuploidy condition in humans, which is associated with various disease phenotypes including cardiovascular, neurological, haematological and immunological disease processes. This review paper aims to discuss the research conducted on gene expression studies during fetal develo...