This article is part of the Special Issue on Immunological Imprinting during Chronic Viral Infection. * Elizabeth Elder ege22@cam.ac.uk * John Sinclair js152@hermes.cam.ac.uk 1 Department of Medicine, University of Cambridge, Box 157 Addenbrooke's Hospital, Hills Road, Cambridge CB2...
"We're converging on a more nuanced understanding of immune imprinting, which I think is a nice lesson from the COVID-19 pandemic," Wesemann said. "Of course, a pandemic is terrible, but putting that aside and looking at how our immune system processes information and seeing biology at wo...
As such, the relationship between the T cell and self is dynamic and evolves over time. Here we discuss the role of the self-immunopeptidome in establishing naive T cell heterogeneity throughout a T cell’s life and ask what the distinct roles of self-mediated thymic imprinting versus ...
Dobosz P, Stempor PA, Ramírez Moreno M, Bulgakova NA (2022) Transcriptional and post-transcriptional regulation of checkpoint genes on the tumour side of the immunological synapse. Heredity https://doi.org/10.1038/s41437-022-00533-1 Dong C, Yoon W, Goldschmidt-Clermont PJ (2002) DNA methylat...
Sex differences in psychiatric disorders are the result of a complex interplay between genetic, hormonal, immunological, and psychosocial factors [2,3,16,17,18,19,20,21,22,23]. Adding to this complexity, the diagnosis of psychiatric disorders is currently based on behaviorally defined DSM criteria...
Another comment often made about the BCG vaccine is that it fails to induce long-lasting immunity, generally assumed to be mediated by classical T-cell memory. Again, this is not correct, as despite concerns about the induction of long-term immunological memory by BCG in mice, in certain set...
this is the absence of Operation Warp Speed-like funding and lack of a pandemic situation, which required prioritization of vaccine development on all levels. Second, the immunological problems that need to be solved with universal vaccines are very different in nature from the simple induction of...
(iii) INDOLE 3-BUTYRIC ACID RESPONSE 5 (IBR5); and, (iv) AUXIN BINDING PROTEIN 1 (ABP1), which is the oldest known putative auxin receptor [5,6]; however, these latest findings were put into question when ABP1 was found to have little, if none, prominent role in Arabidopsis ...