What is IMBRUVICA® (ibrutinib)? IMBRUVICA® is a prescription medicine used to treat: Adults with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Adults with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) with 17p deletion. Adults with Waldenström's ...
Find out about the science and chemistry of Ibrutinib (Imbruvica), see colourful images of Ibrutinib and explore interactive 3D molecules of Ibrutinib
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You should not drink grapefruit juice, eat grapefruit, or eat Seville oranges (often used in marmalades) during treatment with IMBRUVICA®. These products may increase the amount of IMBRUVICA® in your blood. What are the possible side effects of IMBRUVICA®?
Ibrutinib for adults who failed at least 1 treatment for chronic GVHD Mycophenolate mofetil, added to tacrolimus, cyclosporine, sirolimus, and/or prednisone, for steroid-refractory chronic GVHD Azathioprine, alternating cyclosporine/prednisone, or thalidomide for steroid-refractory chronic GVHD Clofazimin...
On the other hand, targeted therapies focus on a specific interaction between cancer cells. One promising new treatment is a drug called ibrutinib (Imbruvica), which has done well in several early studies. Different types of targeted therapy focus on other interactions between cancer cells. ...
For example, ibrutinib (1; Fig. 3), a BTK inhibitor approved for the treatment of several B-cell malignancies including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma, exhibited high potency through covalent binding to a cysteine residue (Cys481) adjacent to the ATP- binding site ...
Your doctor may recommend a kinase inhibitor if you have certain gene glitches, like del(17p) and TP53, or if your cancer comes back after treatment. For some people, they may work better than chemo. Examples include acalabrutinib (Calquence), duvelisib (Copiktra), ibrutinib (Imbruvica), ...
Ibrutinib appears to be highly selective for transformed B cells, "so the results are really quite gratifying," Dr. Keating said. It also appears to have low toxicity. Toxicity is a problem in the treatment of CLL, where the standard therapy is a combination of fludarabine, cyclophosphamide, ...