Although the association between HLA-B27 and ankylosing spondylitis (AS) is well established, the mechanism governing this association remains unknown. Although 90% of affected individuals possess the HLA-B27 antigen, HLA-B27 is also present in 8% of the normal population. This article examines ...
Ankylosing spondylitis is a form of reactive arthritis following Klebsiella infection, usually occurring in an HLA-B27-positive individual. This conclusion... A Ebringer - 《Rheumatic Diseases Clinics of North America》 被引量: 96发表: 1992年 Abnormal high-expression of CD154 on T lymphocytes of...
1 (866) 768-6846 Contact Us Foodborne Illnesses/Reactive Arthritis/ Typically, symptoms last for 3-5 months, and most resolve by a year. However, 15-20% may involve a more chronic persistent arthritis, with joint damage and deformity in some. Those who are HLA-B27 positive are more likely...
Most people who have ankylosing spondylitis have a gene that makes a protein or "genetic marker" called HLA-B27. This gene is involved in your body's immune response, which normally works to protect you against bacteria, viruses, and other harmful substances. But most people who have HLA-B27...
HLAHLA-B27geneticsβ2MAcute anterior uveitis (AAU) is by far the most common form of uveitis [6]. It is characterized by a breakdown in the blood–aqueous barrier and acute inflammation of the iris and ciliary body. Immunopathologically, there is up-regulation of cell adhesion molecules on ...
Doctors don't know exactly what causes AS, but they suspect genes are involved. People who inherit a gene called HLA-B27 are at much higher risk for this type of arthritis. What's the Link Between UC and AS? Both UC and AS are inflammatory diseases. UC inflames the intestine, wh...
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Increased tissue protein synthesis during spontaneous inflammatory bowel disease in HLA-B27 rats. Clin. Sci. (Lond.) 2003, 105, 437–446. [CrossRef] 121. Heys, S.D.; Park, K.G.; McNurlan, M.A.; Keenan, R.A.; Miller, J.D.; Eremin, O.; Garlick, P.J. Protein synthesis ...
Infliximab dose reduction sustains the clinical treatment effect in active HLAB27 positive ankylosing spondylitis: a two-year pilot study A Pearson correlation analysis (r: Pearson coefficient) was performed between the disease specific instruments (BASDAI, BASFI, BAS-G, BASMI) and the items in the...
To establish which of the fluorescence parameters obtained yielded the best discrimination between HLA-B27-negative and B27-positive samples, we constructed ROC plots by using the percentage of positive lymphocytes, the MFI, and the MdFI. As an example, in screening with the HLA-ABC-m3 monoclonal...