Inpharma Weekly -doi:10.1007/BF03311730Springer International PublishingInpharma
Traditionally anti-coagulation was achieved using standard heparin, which necessitated hospitalization and close monitoring of the blood parameters. With low-molecular-weight heparins this is no longer always necessary. Derived from standard heparin, low-molecular-weight heparins have a far lower molecular...
Studies show that factor Xa inhibitors reduce recurrent VTE just as well or better than standard therapies. That includes drugs in the same class, such as low molecular weightheparin(LMWH) andvitamin Kantagonists. There’s some evidence that apixaban may lower the rate of new blood clots more ...
Neuraxial anesthetic techniques are commonly used during the peripartum period to provide effective pain relief for labor and anesthesia during cesarean delivery. Major neurologic complications are rare after neuraxial anesthesia; however, spinal hematom
Dosing of IV UFH should prolong the activated partial thromboplastin time (aPTT) to a range that corresponds to an anti-factor Xa assay (anti-FXa) level of 0.35 to 0.7 U/mL, whereas LMWH should achieve an anti-FXa level of 0.5 to 1.0 U/mL 4 h after an injection for twice-daily ...
While unfractionated heparin and the low molecular weight heparin (LMWH), enoxaparin, is most commonly dosed at 5000 units every 8 h and 30 mg every 12 h, respectively. In TBI evaluation, the anti-factor Xa assay allows for assessment of LMWH within a targeted range without increased risk ...
This chapter describes the essential elements mechanical circulatory support (MCS) teams need to build and maintain robust programs. Feasibility assessment, financial viability, multidisciplinary expertise, sustainable infrastructure, and safe delivery o
PF.59 What is the Optimal Dose of Low Molecular Weight Heparin in Pregnant Women with Raised BMI?Introduction Obesity is a risk factor for thromboembolism in pregnancy. Recent RCOG guidelines suggested a non-evidence based weight-dependent protocol in which monitoring of anti-Xa levels was not ...
[89,132]. Management of acute DVT or PE involves withholding the offending drug if any and starting immediate systemic anticoagulation with low-molecular-weight heparin or unfractionated heparin. LMWH is the preferred anticoagulation at the time of transition to outpatient therapy as evidence suggests ...
Low molecular weight heparin is the ideal substance for prophylaxis and treatment of venous thromboembolism in pregnancy under weekly monitoring of anti-factor Xa activity.doi:10.1007/s00508-019-1529-yIrene M. LangWiener klinische Wochenschrift