Today, PD is exclusively treated symptomatically, mainly by dopaminergic stimulation, while efforts to modify disease progression could not yet be translated to the clinics. New formulations of approved drugs and treatment options of motor fluctuations in advanced stages accompanied by telehealth ...
in terms of solubility it is difficult to replicate the exact peptide characterized from a drug-modified protein during M/S analysis. Often when amino acid residues are altered to enhance the solubility of the synthetic peptide this bears a knock-on effect on the peptide’s affinity...
not surprisingly, always presented difficulties in recruitment. When provided with more complete information about the benefits and risks of the different treatment options before agreeing to randomisation the patients made their own active, informed decisions. This is a well-recognised problem in non...
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A subset of these is described in greater depth to better convey what might be involved in applying OR and Systems Thinking to the IoT. It is suggested that OR has a role to play in balancing the technical and non-technical research challenges which confront the IoT. Keywords: Internet of ...
gdhB , gdhB2 , gidA , gidB , gldH , glnA , glnS , gltX-kdtA , glyA , glyS-BF0355 , gmk-nadD-BF3499 , gnd-zwf-pgl , gno-BF0084 , gpmA-fbaB , gpmI , greA , groEL-BF3220-BF3221 , groES , grpE , guaB , gyrA , hcp , hdhA , hemN...
Although the pathway of hapten-specific T-cell activation is now well established, several questions need to be addressed: first, what is the nature of the hapten-modified peptides displayed by MHC? Second, how many of these peptides stimulate T-cells?; third, what are the critical protein ...
This is the opening paper in the special issue of Fungal Diversity, which collates the data on defining species. Defining and recognizing species has long