Phenylephrine Pharmacokinetics and First-Pass Metabolism: What Is an Ideal Pharmacokinetic Surrogate?AcetaminophenBudesonidePhenylephrineMethyldopaHesperidinClinical Drug Investigation -doi:10.1007/s40261-015-0341-3NuggehallyDrugR.DrugSrinivasDrugClinical Drug Investigation...
首过效应First pass effect:Drugs that are absorbed from the gastrointestinal tract into the bloodstream go first to the liver via the portal vein. Once there,they may be metabolized so rapidly that most of the drug is inactivated before it can reach its site of action. This loss is called~...
Sometimes school closures are long, drawn-out processes. Other times shutdowns can seemingly happen overnight. But the first step for students when they hear the news that their college is closing is to get their records as soon as possible, experts say. Records to gather include transcripts,...
The first part recently transitioned to pass/fail. Step one, typically taken at the end of the second year of medical school, is basic science, biology, the "nitty-gritty" of medicine, but not clinical applications such as how to use medicine to treat a patient, Hernandez...
Investing in physical properties, such as residential or commercial buildings, provides investors with tangible assets that have the potential for rental income and appreciation. "Real estate is like the Swiss Army knife of real asset investing. You can earn money from rent while also banking on ...
Drug discovery, given its interdisciplinary nature, has always been driven by novel developments, whether in the physical sciences (such as organic synthesis) or in the biological sciences (such as the ability to sequence genomes or advances in receptor pharmacology), or, more recently, when applyi...
MFA methods are used to access all kinds of sensitive accounts, assets and systems. They even appear offline: Using a bank card (the first piece of evidence) and PIN (the second piece of evidence) to withdraw cash from an ATM is a form of MFA. ...
If key employees own more than 60% of the assets in a plan, it is considered top-heavy and corrective action may be required. “Failed tests usually either require an employer contribution to the non-highly compensated employees or a refund of contributions from the highly compensated...
Both S corps and LLCs are known as pass-through entities because they pay no corporate taxes. Instead, they pay their shareholders, who become responsible for the taxes due. Key Takeaways An S corp, also known as an S subchapter, is one type of legal business structure common among small...
An export is a good that is produced domestically but sold to a consumer overseas. Exporting goods can have advantages and disadvantages for both the producer and the countries in which they do business. Due to resource constraints, economic policy, and manufacturing strategies of each country, it...