Regulatory authorities recognise the same set of risks and benefits for both oestrogens. Oestrone is no longer commercially available and estriol exerts little or no effect on VMS although it is commonly used as a cream or ovule for treatment of local urogenital symptoms. Transdermal estradiol may ...
the cream is either applied topically to the skin of the vagina or inserted into the vagina using an applicator. In some parts of the world, including most European countries, estriol cream is available by prescription, but in other places, for example the United States and Canada, it is ...