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When found in Escherichia coli and Klebsiella spp., ESBLs confer resistance to extended-spectrum cephalosporins, such as ceftazidime, cefotaxime and cefepime. Hence, ESBLs limit the choice of beta-lactam therapy to carbapenems. A worrisome trend is the increasing number of pathogens found in ...
Introduction: The emergence and spread of isolated carriers of extended-spectrum beta-lactamase (ESBL) have complicated the treatment of nosocomial infections, since its production is not easily identified by the sensitivity tests, routi... RCGD Silva,ACDO Silva,SRD Oliveira - 《Jornal Brasileiro ...
Is piperacillin/tazobactam an effective carbapenem alternative to treat bloodstream infections caused by ESBL-producing enterobacteriaceae. The CDC has categorized extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae infections, such as those caused by Escherichia coli and Klebsiella pneumoniae,...
[16]. It is usually harbored by the epidemic IncI2 and IncX4 CPs and has mainly been identified inEscherichia coli(E. coli) [17]. KPC and NDM are the most prevalent carbapenemases and could hydrolyze almost all beta-lactams;blaKPCandblaNDM, genes encoding KPC and NDM, are frequently ...
In addition, ESBL Enterobacteriaceae spp. are responsible for outbreaks irrespective of location. Antibiotic selection of ESBL-producing Gram-negative pathogens is not just related to the total use of antimicrobial agents in hospitals, but also to the particular use of the fluoroquinolones and second-...
Conjugative transfer facilitates stable maintenance of IncP-1 plasmid pKJK5 in Escherichia coli cells colonizing the gastrointestinal tract of the germfree rat. Appl Environ Microbiol 73: 341–343. CAS PubMed Google Scholar Bahl MI, Lars Hestbjerg H, Søren JS (2007b). Impact of conjugal ...
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The continuous spread of carbapenem-resistant Klebsiella pneumoniae (CP-Kp) strains presents a severe challenge to the healthcare system due to limited therapeutic options and high mortality. Since its availability, ceftazidime/avibactam (C/A) has become
Investigation of plasmid mediated AmpC beta-lactamases in Escherichia coli and Klebsiella pneumoniae isolates by phenotypic and genotypic Extended Spectrum [beta]-Lactamases (ESBL) and AmpC are the two primary [beta]-lactamases producers that are an increasing cause of concern in hospitals as they pr...