An average eGFR varies by age, but in younger adults who are considered healthy, a range of 80-120mL/min/1.73 m2is generally normal. GFR decreases as you get older, but a reduced GFR can cause similar issues in older adults as in those who are younger. Adecrease in GFR could also b...
Shingles, also known as herpes zoster, is a skin disease caused by the return of a chickenpox infection from latently infected nerve cells in the spinal cord or brain. It begins as a painful sensation which is often mistaken for a musculoskeletal injury or even a heart attack. It is soon ...
Although not all of the expectations of the time have been fulfilled, CADD is certainly routinely applied in pharmaceutical research today, covering a wide range of ligand- and structure-based techniques and approaches [2]. Also, when it comes to decision support systems for physicians in the ...
in terms of solubility it is difficult to replicate the exact peptide characterized from a drug-modified protein during M/S analysis. Often when amino acid residues are altered to enhance the solubility of the synthetic peptide this bears a knock-on effect on the peptide’s affinity...
Preliminary data for DW-MRI suggest that ADC measurements have a reproducibility of B15% in a multicentre setting (Koh et al, 2009) but it is most likely to range between 8 and 15%, depending on lesion location, acquisition plane and acquisition protocol. For 1H-MRS reproducibility, data ...
EGFR_TK indicates epidermal growth factor receptor tyrosine kinase. Our expanding knowledge of biomarkers and the interconnections among them is enabling development of more complex tests sometimes embedded into algorithms. Specific diseases, such as non-small cell lung cancer now have multiple tests avai...
Stage 2 CKD: Mild loss of kidney function, eGFR 60-89. Stage 3a & 3b CKD: Mild to severe loss of kidney function, eGFR 30-59. Stage 4 CKD: Severe loss of kidney function, eG FR 15-29. Is GFR 94 normal? Results. A GFR of60 or higher is in the normal range. A GFR below 60...
Given that key components of conserved signaling pathways like Notch, Hedgehog, Wnt, and epidermal growth factor receptor (EGFR) were identified using Drosophila wings models [85,86,87,88,89,90,91], Drosophila wing provides an effective system to evaluate the role of autism and other neurodevelop...
Extended Range Proteomic Analysis (ERPA): A New and Sensitive LC-MS Platform for High Sequence Coverage of Complex Proteins with Extensive Post-Translational Modifications-Comprehensive Analysis of β-Casein and Epidermal Growth Factor Receptor (EGFR) J. Proteome Res., 4 (4) (2005), pp. 1155-...
It is noteworthy that these NGS methods will be applied not only in the late stages but also in the early stages of NS-NSCLC, which would mean patients receive adjuvant TKIs according to their EGFR status [70]. In this context, cytological and blood samples will be certainly more and more...