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Kidney decline is often permanent, leading to the need for dialysis or an organ transplant. That’s why two blood tests—one for creatinine and another for eGFR—are crucial steps in any diagnosis: Creatinine Creatinine is a waste product of muscle metabolism that your kidneys should filter out...
aThe primary objective of the study was to determine if the administration of TARCEVA after standard platinum-based chemotherapy in the treatment of NSCLC resulted in improved progression free survival (PFS) when compared with placebo, in all patients or in patients with EGFR immunohistochemistry (IHC...
Researchers evaluated patients with advanced, nonsquamous, non-small cell lung cancer who had never received treatment and did not have an abnormal EGFR or ALK gene (KEYNOTE-189). In this study, 410 patients received 200 mg of Keytruda every 3 weeks plus chemotherapy (pemetrexed and a platinum...
Saltz LB, Rubin M, Hochster H, et al.: Cetuximab (IMCC225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that express epidermal growth factor receptor(EGFR) [abstract]. Proceedings of the American Society of Clinical Oncology 2001. Alexandria, VA: American...
The recent discovery of activating mutations in EGFR and fusion genes involving ALK has set the stage for... TSK Mok - 《Nature Reviews Clinical Oncology》 被引量: 240发表: 2011年 Research on mental health literacy: what we know and what we still need to know Lung cancer is a complex ...
Given that key components of conserved signaling pathways like Notch, Hedgehog, Wnt, and epidermal growth factor receptor (EGFR) were identified usingDrosophilawings models [85,86,87,88,89,90,91],Drosophilawing provides an effective system to evaluate the role of autism and other neurodevelopment-...
EGFR signaling attenuates Groucho-dependent repression to antagonize Notch transcriptional output Nat. Genet., 37 (1) (2005), pp. 101-105 Google Scholar Hayward et al., 2005 P. Hayward, K. Brennan, P. Sanders, T. Balayo, R. DasGupta, N. Perrimon, A. Martinez Arias Notch modulates Wnt...
The immune system plays a major role in the eradication of tumor cells, but is bypassed by the tumor at the clinical expression phase. Various antitumor immune mechanisms are inhibited by efficient escape mechanisms. The treatments currently used in CRC (cytotoxic chemotherapy, anti-EGFR antibodies,...
There is no end to the scenes of murine mass-murder! Clockwise from left: Fig 2G from “CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to Erlotinib via transcriptional regulation of EGFR” (Wang et al 2014); Fig 6D from “JARID1B promotes metastasis and epith...