A letter to the editor is presented in response to the article related to the approach used for the second-line treatment of non-small-cell lung cancer with wild-type epidermal growth factor receptor (EGFR) by Ibrahim Elghissassi in the previous issue.Kim Anh Ma...
et al. Genotypic and histolgical evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci. Transl Med. 3, 75ra26 (2011). PubMed PubMed Central Google Scholar Niederst, M. J. et al. RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung ...
Exblifep is administered as 2.5 grams (2 grams cefepime / 0.5 grams enmetazobactam) every 8 hours by intravenous (IV) infusion over 2 hours for 7 to 14 days. Dosage adjustment is recommended in patients who have an eGFR < 60 mL/min or > 130 mL/min. Fetroja...
For example, mutations in BRAF, EGFR, HER2, and KRAS genes are associated with advanced solid cancers. Cells DNA Genes Alterations Biomarkers Image Biomarkers Biomarkers are measurable characteristics within a cancer cell. The status of certain biomarkers may predict response to immunotherapy ...
Such knowledge helps to guide the generation of the correct genomic context in animal models of human cancer and helps to prioritize the validation of potential drug targets. DNA in vivo is often sharply distorted away from the canonical Watson–Crick structure; different DNA sequences vary greatly...
Body size (body surface area) An equation used by health care providers to confirm your eGFR is the CKD-EPI Creatinine Equation: eGFRcr= 142 x min(Scr/κ, 1)αx max(Scr/κ, 1)-1.200x 0.9938Agex 1.012 (if female) where: Scr= standardized serum creatinine in milligrams per deciliter ...
Cystatin C was introduced as a potential alternative or supplement to the estimation of glomerular filtration rate (GFR) using creatinine. Although cystatin C is well supported as a better predictor of outcomes than creatinine, its reflection of actual renal function compared with creatinine is widely...
Given that key components of conserved signaling pathways like Notch, Hedgehog, Wnt, and epidermal growth factor receptor (EGFR) were identified usingDrosophilawings models [85,86,87,88,89,90,91],Drosophilawing provides an effective system to evaluate the role of autism and other neurodevelopment-...
Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway. Stem Cells 31, 248–258 (2013). Article CAS PubMed Google Scholar Marotta, L. L. et al. The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24...
The reduced efficacy of the EGFR inhibitor (cetuximab) is due to the adverse effect of the over methylation of the MSI-H tumor on the EGFR inhibitor, resulting in the low expression of the EGFR ligand. Because the vascular normalization induced by bevacizumab can enhance the infiltration and ...