2Preclinical safety & Toxicity testing①In vivo-animal studies→Pharmacology and Behavioral Pharmacology→Potency and Efficacy—ED50②Tolerance and Tachyphylaxis→Toxicity-Acute and Chronic—Ld50③Teratogenicity(birth defects) Carcrnogenicity(cancerance)临床试验(2~10年)3Evaluating Drugs in Humans:Phases ...
Cilostazol (Pletal) inhibits PDE3. This inhibitory effect makes red blood cells more able to bend. This is useful in conditions such as intermittent claudication because cells can more easily be maneuvered through constricted veins and arteries. Zaprinast inhibits the growth of the asexual bloo...
The duration of application and the amount is an important factor to be considered. In a study a paired, split-body study of children who received single as well as multiple applications of SPF-25 up to 6 hours of direct sunlight exposure indicated no difference between the two groups. ...
The molecular target for retigabine was identified by comparing the properties of the current induced by retigabine (non-desensitizing, linear current-voltage relationship over a wide range) and its pharmacology (weakly tetraethylammonium (TEA) sensitive, blocked by Ba2+, insensitive to 4-aminopyridine...