The concepts of IC50 and EC50 are fundamental to pharmacology. The EC50 is the concentration of a drug that gives half-maximal response. The IC50 is the concentration of an inhibitor where the response (or binding) is reduced by half. Seems simple enough. But when you actually go to fit d...
However, MX-phos- phate is less efficient than KG-501 (IC50 9.7 µM vs 6.9 µM), while AS-TR-phosphate is more potent, as decreased anchor- age-independent growth and cyclin expression were detected at lower concentrations (IC50 3.7 µM) [104]. The...
In fact, SE is the standard deviation of the fitted parameter obtained from the nonlinear regression. There is no difference between SE and SD when we talk about fitted parameters in the curve fitting. Keywords:SE, SD, parameter, nonlinear curve fit, standard error, standard deviation...
The dataset contains a total of 1,061,462 GPCR-ligand interactions with information on ligands and the binding affinities (Ki, Kd, IC50, EC50, pKB, pKi, pKd, pIC50, pEC50). In addition, it contains information on each ligand’s SMILES (Simplified Molecular Input Line Entry Specification—...