In particular, docking and molecular dynamics calculations highlighted differences in the shape of HDAC surfaces surrounding the binding site. Moreover, the relatively high flexibility of the HDAC6 pocket allowed protein conformational changes by accommodating the cap portion of the studied ligands. These...
Histone deacetylase (HDAC) inhibitors have been demonstrated to be beneficial in animal models of neurodegenerative diseases. Such results were mainly associated with the epigenetic modulation caused by HDACs, especially those from class I, via chromatin
The NanoStim LP was withdrawn from the market between 2016 to 2017 after battery malfunctions that caused problems with telemetry and pacing, as well as reported detachments of the docking button. Each LP had its pivotal trial (LEADLESS II, Abbott NanoStim; Reynolds et al., Medtronic Micra; ...