(MSD), was approved to treat patients with solid tumours that are high microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR). Previously, the FDA had approved cancer therapies based on where the cancer originated, such as lung or breast cancer. This time, medic...
Scientists have found that some of the mechanisms of action of drugs suitable for MSI-H treatment, such as PD-L1 (programed cell death ligand 1) immunosuppressant, can produce heteroantigens that are easy to be recognized by T cells in dMMR cancer cells, which is beneficial to a variety ...
For the first time, a PD1 ICI (pembrolizumab) has been approved by the European Medicines Agency (EMA) for first-line treatment of advanced (stage IV) dMMR/MSIH colorectal cancer (CRC). Further indications, such as dMMR/MSIH endometrial carcinoma (EC), have already succeeded (Dostarlimab...
Robert Coleman, MD, FACOG, FACS: Mike, is this a typical presentation for a patient who has uterine-confined endometrial cancer?Michael J. Birrer, MD, PhD: This a typical presentation with a couple of caveats. First, from a clinical biologic standpoint, she has a fairly high BMI [body ...
In the field of sporadic CRC, the BRAF mutation is strongly associated with MMR deficiency. Considering breakthrough results of immune checkpoint inhibitors in dMMR repair tumors, determination of the MMR status appears to be mandatory. Given the dramatic prognosis conferred by the BRAF mutation, ...
When cancer first spreads and forms micrometastases, the only way to detect them is to remove the tissue where they are located and look at slices under a microscope. This is known as a lymph node biopsy. However, it’s impossible to remove and examine every lymph node and organ in the...
(programed cell death ligand 1) immunosuppressant, can produce heteroantigens that are easy to be recognized by T cells in dMMR cancer cells, which is beneficial to a variety of MSI-H tumors [54]. At present, there are researches on specific tumor targets of MSI. After analyzing multiple...
What is Polymerase chain reaction (PCR) Test? COVID-19 PCR test will be taken to detect the antigen presence and will determine the person has positive or negative for COVID 19. How to get ready for PCR test? Get prepared for your PCR test For the COVID-19 PCR test, ...
Introduction Targeted alpha-particle therapy (TAT) is the most rapidly developing field in nuclear medicine and radiopharmacy. The basic advantage of TAT over commonly used β− emitting radionuclides therapy lies in the irradiation of fewer cancer cells, micrometastases or tumors by an emission of...
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