Today there are thousands of examples of the use of DMAP in far ranging fields of chemistry in both patents and the research literature. Many full-scale production processes utilizing DMAP have been and are being operated. Several pharmaceutical and agricultural products that rely on DMAP’s ...
It is important to note that, accelerated by enhanced research in green chemistry, significant efforts are on-going in the use of earth-abundant metals such as iron to replace more toxic or expensive transition metals, thus somewhat mitigating one of the advantages of organocatalysis. Examples ...
In the acylation of phenols, DMAP and PPY effect a similar increase in reaction rate as is found in the case of alcohols. Hence, the method is of interest for the acylation of sterically hindered phenols. For example, mesitol can be smoothly acetylated with acetic anhydride/DMAP to 2,5-di...
RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook Category filter: AcronymDefinition DMAP4-(dimethylamino) pyridine DMAPDirect Matrix Abstraction Program(macro language of NASA Structural Analysis System) DMAPDivision of Medical Assistance Programs ...
In organic chemistry, an imide isa functional group consisting of two acyl groups bound to nitrogen. The compounds are structurally related to acid anhydrides, although imides are more resistant to hydrolysis. Is DMAP a base? In this case, DMAPacts as a baseand deprotonates the phenol, and ...
In a dry reactor, DMAP (2.4 equivalents) is added to a suspension of 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride (1.3 equivalents) in dichloromethane (1M), and the mixture is stirred at room temperature until all solids are dissolved. Pent-4-enoic acid (0.25 mL, 2.5 mmol) and...
The main applications of EDAC are in peptide synthesis, Steglich esterification reactions in presence of catalytic DMAP, immunoconjugate synthesis, synthesis of sulfo-NHS esters and coupling of biomolecules onto solid supports. Biochem/physiol Actions N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide is a...
(PMDETA, 99%, Aldrich), methanol ([greater than or equal to] 99.9, Aldrich), N, NThicyclohexylcarbodiimide (DCC, 99%, Aldrich), 4-(dimethylamino) pyridine (DMAP, [greater than or equal to] 99.99%, Aldrich), propiolic acid (99%, Aldrich), and N, N-dimethylformamide (DMF, 99%, ...
While most researchers in the field pack their columns in the laboratory, this is not a viable option in the industry. However, the significantly lower stationary phase required to pack a miniaturized column also enables the exploration of innovative materials with diversified chemistry, such as ...
The cork layer present in all dicotyledonous plant species with radial growth is the result of the phellogen activity, a secondary meristem that produces phellem (cork) to the outside and phelloderm inwards. These three different tissues form the perider