Dextran is a complex branched glucan (polysaccharide derived from the condensation of glucose), originally derived from wine. IUPAC defines dextrans as "Branched poly-α-d-glucosides of microbial origin having glycosidic bonds predominantly C-1 → C-6".[1] Dextran chains are of varying lengths (...
High-molecular weight dextran is a plasma volume expander made from natural sources of sugar (glucose). It works by restoring blood plasma lost through severe bleeding. Severe blood loss can decrease oxygen levels and can lead to organ failure, brain damage, coma, and possibly death. Plasma is...
Cellulose acetate butyrate microcapsules containing dextran ion-exchange resins as self-propelled drug release system. Biomaterials, 2005, 26: 4337–4347 Article Google Scholar Märtson M, Viljanto J, Hurme T, et al. Is cellulose sponge degradable or stable as implantation material? An in vivo...
This paper is my annual oration on prevention of multiple organ dysfunction syndrome (MODS) and multiple organ failure (MOF) at the Organ Failure Academy in Trieste, Italy. All we can do to treat MODS and MOF is organ support. Therefore, prevention is th
(Caco-2) by inhibiting p38 cascade phosphorylation and upregulating the NF-κB signaling pathway. Gao et al. [38] found that Chlorogenic acid regulates the amino terminus of Mitogen-activated protein kinase (MAPK)/ERK/c-Jun in the dextran sulfate-induced ulcerative colitis model in mice. Kinase...
Damage to the colon mucus barrier, the first line of defense against microorganisms, is an important determinant of intestinal diseases such as inflammatory bowel disease and colorectal cancer, and disorder in extraintestinal organs. The mucus layer has
compounds from passing, unless being lipophilic, or coming from systemic absorption or via the nasal route (nose-to-brain), not intranasal, across the olfactory mucosa [128], with the recommended use of cell penetration peptides onto the NPs as dextran nano-micelles or bio-muco-adhesive nano-...
4.1. Effect of Amino Acid Supplementation on Intestinal Inflammation Resolution In the rat model of colitis treated with Dextran Sodium Sulfate (DSS), supplementations with threonine, serine, proline, and cysteine or with threonine and cysteine only, promote mucin synthesis and increased mucin ...