This PAM sequence is specific for each Cas protein. For the most commonly used SpCas9, NGG somewhat limits the choice of a target sequence. Although there are sufficient NGG positions in each genome, if one needs to cut at a specific place due to a functional amino acid or protein domain...
But it is still freezing, not as bad as usual, but its only a matter of time before it is completely unusable. When it freezes i get the beach ball but can usually move the cursor. The freeze starts randomly but especially when doing something 'difficult' like watching a video, or ...
Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal disease characterized by the accumulation of fibrotic tissue in the lung [1]. While two antifibrotic medications (nintedanib and pirfenidone) [2,3] have been shown to slow disease progression and are currently in use, a signific...
(Nematoda: Anisakidae) is the etiological agent of the gastrointestinal zoonotic disease known as anisakiasis. The genus Anisakis includes nine species distributed worldwide, and two of them are mainly associated with human infections [3]: Anisakis simplex sensu stricto, occurring in the subarctic ...
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The University of California Office of the President (UCOP) has been concerned about the disproportionately low rate of some racial/ethnic groups on campuses of the University of California (UC) and is committed to increasing the enrollment of traditionally underrepresented racial and ethnic groups on...
Anybody who had to compete with the mobile phone of one's communication partner at the dinner table for communicative attention can attest to this, and this is pervasive: 89% Americans used their phone during the most recent social gathering [3]. Embracing traditional and new communication ...