Present in inactive joints, the crystal surfaces are bare; in acute gout, the crystals are covered with mucin, confirming the observation that protein binding to crystals is necessary for inflammation to proceed. CPPD disease is by far the most common crystal-associated arthropathy affeting the ...
have shown the inhibition of pyrophosphatase by copper ions in vitro, which explains the accumulation of CPPD crystals.3 The spinal abnormalities can be osteophytes, disc space narrowing, squaring of ver- tebrae, and Schmorl's nodes that predominate in middorsal...