The depressive disorder symptoms are common when considered in isolation but constitute an illness when depression symptoms occur in a group. For example, many people experience sleep disturbance (oversleeping or undersleeping) and taken alone, this is not amental illness, but when that occurs for ...
The objective of this research was to examine treatment patterns and health-care costs associated with second-step pharmacotherapy in patients with major depressive disorder (MDD) who initiated monotherapy with a selective serotonin reuptake inhibitor (SSRI) in 2010. Methods This claims database study ...
Ideally, with treatment, a patient would achieve remission of MDD, defined as being free or nearly free of symptoms. However, achievement of remission may be difficult to obtain with monotherapy treatment. For example, in the National Institute of Mental Health (NIMH)-funded Sequenced Treatment ...
terms of efficacy and tolerability in using them as antidepressants to treat PPD. Furthermore, a Cochrane review on three studies comparing SSRIs with placebos for PPD was conducted by Molyneaux et al. [46], which reported that patients did exhibit response and remission to the treatment [47]...
Therapy resistance responses outlined above were discovered largely by the use of high-resolution microscopy and observations for long times (weeks) following genotoxic insult. Studies considered in this section illustrate the consequences of ignoring such responses, as a result of relying on preclinical...
N-acetylcysteine (NAC), a form of the amino acid cysteine, is widely used in emergency medicine to treat individuals who overdose on acetaminophen or paracetamol. Placebo-controlled studies have investigated the effectiveness of NAC as a treatment of major depressive disorder, bipolar disorder, ...
Metabolomics is considered as a powerful tool to gain insight into the molecular mechanisms targeted by pharmacotherapies [86]. Pharmacometabolomic studies using animal models have been used to investigate the effects of chronic treatment with antidepressants, as the long-term effects of most ...