delamanidtuberculosisBedaquiline and delamanid used to treat extensively drug-resistant tuberculosis are known to cause prolonged QTc. Two children with extensively drug-resistant tuberculosis were put on bedaquiline and delamanid and had prolonged QTc on the Bazett formula but normal QTc by the Fridericia...
In stable sinus rhythm, a QT interval corrected for heart rate (QTc) of > 0.44 sec is considered abnormal. In this study, in the presence of sinus arrhythmia, the QT interval following the shortest RR interval was > 0.46 sec in 98.4% of patients with the congenital long QT syndrome, ...
If the patient has a prolonged QTc at baseline (>450 ms in men and >460 ms in women in the absence of interventricular conduction defects), it is important to try to avoid all QT-prolonging medications.47 Although this is not an absolute contraindication to starting QT-prolonging drugs, ...
(0.26 sec) compared with the PR intervals of the other sinus complexes. Because every third QRS complex is a PVC, this is ventricular trigeminy. The QT/QTc intervals are normal (400/400 msec and 360/360 msec when the prolonged QRS complex duration is considered)....
The latter two also carry boxed warnings for cardiopulmonary arrest/sudden death and are associated with hypomagnesemia (electrolytes should be monitored) but not QTc prolongation [63, 64]. The anti-CD22, moxetumomab pasudotox, has a boxed warning for capillary leak syndrome (CLS), a rare ...
(QTc)intervalisquestionableinmany casesandshouldbesupplementedbymanualreading.Incon- sistencybetweenmanufacturersintermsofthealgorithms usedforcalculationoftheintervalsisanotherproblemin theinterpretationofcomputerizedreadings.Somedigitiz- ingmethodsemployadigitizingpad,magnifyinglamp,and pointingdevicetoidentifythe...
Aortic stenosis is a common valvular pathology and may also have atypical presentations outside the classic triad of chest pain, syncope, and shortness of breath. Some patients may not present with the symptoms of the triad. This patient instead presented with syncope and vomiting. Statistically,...
His baseline electrocardiogram (ECG) demonstrated a normal sinus rhythm and a QT/QTc of 484/475 milliseconds at a pulse of 58 beats per minute. The patient was given 20 mg intramuscular ziprasidone for agitation. He developed palpitations and weakness 45 minutes after receiving ziprasidone. His ...
Aspergillus is considered a nosocomial agent; however, there is no current uniform definition of what constitutes nosocomial aspergillosis. One of the main reasons for defining hospital-acquired aspergillosis is that the incubation period for Aspergillus is unknown [52]. In addition, the prolonged ...
If QTc prolonged on EKG, an alternate drug may be needed. Drug interaction: Conivaptan: could increase concentration ofCYP3A4 substrate. ESRD: Transdermal patch suggested to not be used with ESRD (MW 336; lipophilic; Vd 4 L/kg). CKD: Reduce dose by 50%; limited information on other ...