A cluster randomised controlled trial is a type of randomised controlled trial in which groups of subjects are randomised. Cluster randomised controlled trials are also known as cluster randomised trials, group-randomised trials, and place-randomized trials. What is a cluster randomized equivalence trial?
Cluster analysisHealth services researchRandomized controlled trial as topicThe basic premise of a stepped wedge cluster randomised trial (SW-CRT) is that all clusters start in the control condition, and they switch to the intervention condition in an order determined by randomisation. SW-CRTs differ...
We use the Well London cluster randomised trial as a case study. Local adaptation is a commonly cited feature of complexity, as are complicated intervention delivery logistics and interactions between multiple intervention components. A key unresolved objection to the use of controlled trials for ...
The Well London program--a cluster randomized trial of community engagement for improving health behaviors and mental wellbeing: baseline survey results. Trials. 2012;13:105. Derges J, Clow A, Lynch R, Jain S, Phillips G, Petticrew M, et al. 'Well London' and the benefits of ...
In this cluster randomized trial (N = 1060), we tested the impact of financial incentives (5 voucher vs. 200 lottery) framed as a gain or loss to promote Chlamydia screening in students aged 18–24 years, mimicking the standard outreach approach to student in halls of residence. Compared to...
One-year intensive lifestyle intervention and improvements in health-related quality of life and mental health in persons with type 2 diabetes: a secondary analysis of the U-TURN randomized controlled trial. BMJ Open Diabetes Res Care. 2021;9(1): e001840. Article PubMed PubMed Central Google ...
One of the cluster randomized controlled trials (RCTs) found no significant differences between the intervention and control groups [19]. It is important to note that while each of these seven studies was evaluating a visiting service, the emphasis was generally on the service itself rather than...
Oliveira JS, Sherrington C, Rissel C, Howard K, Tong A et al. Effect of a coaching intervention to enhance physical activity and prevent falls in community-dwelling people aged 60 + years: a cluster randomised controlled trial. Br J Sports Med. 2024. ...
Placental growth factor testing to assess women with suspected pre-eclampsia: a multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial. Lancet. 2019;393:1807–18. Article CAS PubMed PubMed Central Google Scholar Verlohren S, Herraiz I, Lapaire O, Schlembach D, Moertl M, ...
immune cells or other biomarkers or the prescription of mechanism-based therapies such as antivirals, anti-inflammatories or anticoagulants. Low-dose naltroxone, for example, is currently being tested in at least one randomized controlled trial (see National Clinical Trials Registry NCT05430152), whi...