Nature Reviews Molecular Cell Biology16,651–664 (2015)Cite this article 60kAccesses 338Citations 25Altmetric Metrics Key Points Ribosome profiling is a deep-sequencing-based tool that allows the detailed measurement of translation globally andin vivo. ...
Phagocytosis is the process by which a cell or a single-celled organism engulfs and consumes another cell or single-celled organism. Phagocytosis plays an important role in your immune system because it is how certain immune cells seek out and destroy foreign and potentially harmful cells....
One of the first studies applying a large-scale characterization of proteins inB. xylophilusfocused on nematode surface coat (SC) proteins [99]. The nematodes SC is the outer layer of the cuticle that is recognized to have several different functions, from acting as an exoskeleton maintaining bo...
The scattered laser light is captured by a charge-coupled device camera, and a spectrum is obtained that has discernable peaks for different biological molecules in the cell. When tested on single microbial cells, the peaks in the Raman spectra corresponding to phenylalanine, proteins and nucleic ...
Nevertheless, the elucidation of the nature and cell location of the involved proteins underlying such common clinical and pathological features is crucial to disentangle the affected pathways and to ascertain common processes. NCL-associated proteins (CLN1 to CLN14) differ in their function and their...
Is one [protein] more important for calcium exchange and another set of proteins more important for lipid exchange?" Golden asked. "I think there's a lot of cell biology that we just don't know and could be answered [using this method]." ...
These advances are described below, together with a discussion of the principal mechanisms of PDT-induced cell killing and a review of the most interesting clinical applications. The infrastructure of a radiotherapy department is well suited to accommodate PDT, which requires strong physics support for...
The evolution of molecular biology and recombinant protein technology has had a significant impact on the field and resulted in ways to generate therapeutic proteins which are functionally equivalent to proteins derived directly from the plasma. The best example of this is Factor VIII for the ...
suggests that results may vary according to these variables. To date, it is probable that surgery remains, in some cases, the best solution even if mutilating. If results of salvage surgery have been evaluated after conventional XRT, little is known about salvage after altered fractionation XRT ...
Colloquially referred to as the “multiple fills” strategy [44,45], this method is performed by sequentially storing ion packages in the C-trap (or, possibly, HCD cell) prior to their transfer to the Orbitrap. However, this approach is rarely utilized in TDP experiments due to various ...