What is triple negative breast cancer? Triple negative breast cancer(TNBC) means that the cancer cells do not have estrogen (ER) and progesterone (PR) on their surface, and they do not over-express the HER2 protein as well (HER2−). In contrast to TNBC, triple positive breast cancer mea...
Addressing Residual Disease in HER2-Positive and Triple-Negative Breast Cancer: What Is Next?Breast cancerNeoadjuvant therapyAdjuvant therapyOlaparibPembrolizumabCapecitabineT-DM1To summarize the treatment strategies for patients with human epidermal growth factor receptor 2 (HER2)-positive disease and triple-...
” Dr. Rodgers adds. Triple-negative breast cancer means the cancer does not have receptors for estrogen or the related hormone progesterone and is also negative for overexpression of the HER2 protein, a type of protein fueled by a certain gene, also calledHER2, that contributes to cancer cell...
Cancer subtype Aggressive cancers cause earlier deaths among people with breast cancer. Some subtypes of aggressive breast cancer, like high-grade tumors called triple-negative tumors, are twice as common among Black women, especially younger Black women, as compared to their White peers. These cance...
Secondary Liver Cancer: Secondary liver cancer is a cancer that develops in some other organ and then spreads to the liver. The most common cancer that spread to the liver include breast, bowel, and lung cancer. A primary cancer is where the cancer begins before it metastasizes. Some of th...
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Stephanie Graff, MD, FACP: In the adjuvant setting, I am excited about some of the trials that are going on that are going to be looking at questions around triple-negative breast cancer. I guess I can say that I kind of hate KEYNOTE 522 [NCT0303...
Triple-negative breast cancer (TNBC):The breast tissue lacks estrogen receptors, progesterone receptors, andHER2protein receptors that control how cells grow and divide. Triple-negative breast cancer is often more aggressive and more challenging to treat. ...
This August, Celldex enrolled the last of 327 women with triple-negative breast cancerandtumors that overexpress gpNMB, a cell surface protein the company's lead candidate targets. Glembatumumab vedotin, or glemba, shakes hands with gpNMB on its way into tumor cells where it delivers a lethal...
acting as a tumor suppressor in ER-positive subtypes, and a potential oncogene in AR-positive Triple-Negative Breast Cancer (TNBC) [108,109]. These nuanced roles underscore the need to explore the subtype-specific implications of AR in BrCa while leveraging insights from PCa to guide therapeutic...